Three-dimensional laser-induced photoacoustic tomography of mouse brain with the skin and skull intact.

نویسندگان

  • Xueding Wang
  • Yongjiang Pang
  • Geng Ku
  • George Stoica
  • Lihong V Wang
چکیده

Three-dimensional laser-induced photoacoustic tomography, also referred to as optoacoustic tomography, is developed to image animal brain structures noninvasively with the skin and skull intact. This imaging modality combines the advantages of optical contrast and ultrasonic resolution. The distribution of optical absorption in a mouse brain is imaged successfully. The intrinsic optical contrast reveals not only blood vessels but also other detailed brain structures, such as the cerebellum, hippocampus, and ventriculi lateralis. The spatial resolution is primarily diffraction limited by the received photoacoustic waves. Imaged structures of the brain at different depths match the corresponding histological pictures well.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Noninvasive imaging of hemoglobin concentration and oxygenation in the rat brain using high-resolution photoacoustic tomography.

Simultaneous transcranial imaging of two functional parameters, the total concentration of hemoglobin and the hemoglobin oxygen saturation, in the rat brain in vivo is realized noninvasively using laser-based photoacoustic tomography (PAT). As in optical diffusion spectroscopy, PAT can assess the optical absorption of endogenous chromophores, e.g., oxygenated and deoxygenated hemoglobins, at mu...

متن کامل

Study of Genes Expression Involved in Apoptosis (Bax, Survivin) After Induced Cold Injury on Sensorimotor Cortex of Mouse Brain and Treatment With Magnesium Chloride

Purpose: The purpose of this study was to investigate the expression of Bax and surviving after cold injury and the ability of magnesium chloride to inhibit of apoptosis. Materials and Methods: To produce cold injury, a metal probe cooled with liquid nitrogen was applied to the surface of the mouse intact skull above the parietal lobe by force of 100 gr for 30 sec. Brains were removed 72 h aft...

متن کامل

Three-Dimensional Computed Tomography Diagnosis of Cranium Bifidum with Meningocele in a Lamb

Abstract   Case Description- A three-day-old male Kordi lamb had a soft painless fluctuating mass on the mid-parietal region, with no clinical signs except difficulty in standing; was referred to the clinic. Clinical Findings- Clinical examination revealed a normal body temperature, a heart rate, a respiratory rate, and inability to stand without any congenital defects Three-dimensional comp...

متن کامل

Monkey brain cortex imaging by photoacoustic tomography.

Photoacoustic tomography (PAT) is applied to image the brain cortex of a monkey through the intact scalp and skull ex vivo. The reconstructed PAT image shows the major blood vessels on the monkey brain cortex. For comparison, the brain cortex is imaged without the scalp, and then imaged again without the scalp and skull. Ultrasound attenuation through the skull is also measured at various incid...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Optics letters

دوره 28 19  شماره 

صفحات  -

تاریخ انتشار 2003